Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 177
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Physical Properties.-This drug is a white, crystal-
line, tasteless powder having a slight aromatic odor; it
has a melting-point of from Io7.6 to Io9.4 F. (42 to
43 C.).
Solubility.-Salol is soluble in alcohol, ether, turpen-
tine, sandalwood oil, copaiba balsam, and the fixed oils;
it is insoluble in water.
Therapeutic Applications.-Salol has decided anti-
septic, antipyretic, and antirheumatic properties. It has
largely been used as a substitute for the salicylates in
the treatment of rheumatism. This drug is said to be of
value in diseases of the urethra and bladder, such as
gonorrhoea, cystitis, etc., and also in inflammatory affec-
tions of the pharynx and respiratory tract, such as colds
in general, bronchitis, and catarrhal fever. This remedy
has been found serviceable against diarrhoea and other
intestinal disorders of children. Salol has also rendered
good service, locally applied, in the treatment of acute
coryza and of skin diseases, especially in eczema, im-
petigo, and sycosis. This medicament has been tried,
with alleged good effect, in Asiatic cholera, yellow fever,
and even in leprosy. Recently the drug has been em-
ployed with apparently excellent effect, subcutaneously
injected, in the treatment of tubercular phthisis. Under
its influence, it is claimed, the fever and night-sweats
subside, and the cough, as well as the number of bacilli
in the sputa, is considerably diminished, there occurring
at the same time a general improvement and an increase
in the bodily weight.
Administration.-The dose of salol (best given in
cachets or suspended in milk) is from 5 to 30 grains
(0.3 to 2 grammes), or even as high as 2 drachms (7.8
grammes) a day. Externally, this remedy may be em-
ployed as a dusting-powder (salol and chalk or starch,
equal parts or I to 3), in the form of gauze, ointment, col-
lodion (4 to 4 of ether and 30 of collodion), or in alco-
holic solution of the strength of from 5 to Io per cent.'
1 Salolcamphor is a mixture of salol and camphor in the proportion of 3
12SAL OL.
177
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/176/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.