Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 178
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178 NOTES ON THE NEWER REMEDIES.
SALOPHEN.
Salophen, a derivative of salol, is said to be a salicylate
of amidophenol; it may be considered as salol in which
an atom of hydrogen in the phenyl is replaced by the
monivalent group. Salophen contains 50.9 per cent. of
salicylic acid, its formula being
OH
C6H N /H
COOCH COCH.
Physical Properties.-This drug, which occurs in
small white lamellar crystals, without odor or taste, has
a melting-point of from 368.60 to 370.4 F. (187 to
188 C.).
Solubility.-This remedy is freely soluble in alcohol,
alkali, and ether. Ferric chloride produces a violet
color in the alcoholic solution.
Therapeutic Applications.--Salophen is employed as
an excellent substitute for salol in all those affections for
which the latter medicament is used. This derivative is
said to be of special value in the treatment of acute rheu-
matic arthritis. It has been employed with advantage
also in habitual cephalaigia, in supraorbital neuralgia,
and in migraine.
Administration.-Salophen is given in daily doses of
from I to I I drachms (3.4 to 5.85 grammes).
to 2 parts. It occurs as a colorless, oily liquid, readily soluble in chlor-
oform, ether, and the oils, but insoluble in water. This prel)aration has
been highly recommended as a local application in the treatment of puru-
lent inflammations of the middle ear. A/kol, which is an isomer of bet l,
is the salicylic ether of alpha-naplihthol. The therapeutic action of alphol
is said to be similar to that of salol. Pancreatic and the intestinal juices
decompose alphol into salicylic acid and alpha-naphthol. The new remedy
is recommended as antiseptic, antineuralgic, and antirhcumatic. It has
rendered good service in the treatment of gonorrhvic cystitis. The dose
varies from 8 to 15 grains (0.5 to I gramme), and even as high as 30 grains
(2 grammes).
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/177/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.