Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 181
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SCOPARINE.-SCOPOLAMINE.
(0.03 gramme), or 5 grains (0.30 gramme) in the course
of the day.
SCOPARINE.
This principle is extracted from the common broom-
plant, Cytisus scoparius.
Therapeutic Applications.-The chief properties of
scoparine are those of a diuretic, and as such it has been
tried with apparent success.
Administration.-The dose of scoparine is from 8 to
15 grains (o.5 to I gramme); hypodermatically, - to I
grain (o.03 to 0.06 gramme).
SCOPOLAMINE.
This alkaloid is obtained from Scopolia atropoides.
The hydrochloride or hydrochlorate of scopolamine is the
salt generally used in practical medicine.
Physiological Action.-In small doses scopolamine
has no action on the nervous system. Unlike atropine,
in therapeutic amounts it has a depressant effect upon
the circulation, diminishing the pulse-rate. Large quan-
tities, however, cause a rise of the arterial pressure by a
vaso-motor stimulation centrally. As an antiphlogistic
it resembles hyoscine. The secretion of saliva and of
sweat is diminished by scopolamine. This drug also
paralyzes accommodation and dilates the pupil. Scopol-
amine has apparently no action on the respiratory func-
tion. It is rapidly eliminated by the kidneys.
Therapeutic Applications.-The medicament under
consideration is mainly used as a substitute for atropine.
Scopolamine, unlike atropine, does not excite the cere-
brum, this being considered an advantage. In fact,
scopolamine is said to decrease the excitability of the
brain.
Administration.-Scopolamine hydrochloride may be
given in doses of from 2I to I of a grain (0.00025 to
o.oor gramme).
Contraindications.-Disturbed nutrition and renalI81
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/180/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.