Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 179
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SANG UINA RINE.-SA NTONIN- OXIM.
SANGUINARINE.
An alkaloid extracted from the root of the common
blood-root plant (Sanguinaria canadensis). The salt
of this alkaloid recently tried in practical medicine is
the nitrate, the composition of which is given as
C,1,7-INO4H NO3.
Therapeutic Applications.-Nitrate of sanguinarine
has been used as a general tonic and stimulant, as an
expectorant, and also as a purgative and emetic. The
emetic effects are produced only by comparatively large
doses.
Administration.-The dose of sanguinarine nitrate
varies from 112 to g of a grain (0.0054 to o.oo8I gramme).
As an emeto-cathartic it may be given in quantities of
from z to I grain (0.032 to 0.064 gramme).
SANTONIN-OXVI.
A derivative of santonin. It is obtained by the action
of an alcoholic solution of hydrochlorate of hydroxyl-
amine on santonin, and the addition of soda. Its for-
mula is given as C1,HsO2,NOH.
Physical Properties.-This new body appears in the
form of a white crystalline powder having a melting-point
of 323.6 F. (162 C.).
Solubility.-This drug is soluble in alcohol and in
ether, and difficultly soluble in water.
Therapeutic Applications.-Santonin-oximn has been
chiefly employed as a substitute for the mother-substance,
to which it is claimed to be superior as an anthelmintic,
owing to its lack of poisonous properties.
Administration.-The dose of santonin-oxim varies
from I to 5 grains (o.o6 to 0.30 gramme), as follows: for
a child two to six years of age, I to I2 grains (o.o6 to
o.o9 gramme); six to nine years, 2 grains (o. 12 gramme);
for adults, 5 grains (0.30 gramme). The dose is to be
divided into two parts and given at intervals of from one
to two hours, to be followed by a cathartic.I79
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/178/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.