Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 174
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174 NOTES ON THE NE WER REMEDIES.
CO
C6H,4 /NH.
SO2
Physical Properties.--'This substance occurs as a
white powder having an intensely sweet taste and an
odor slightly resembling that of almonds.
Solubility.-This drug is soluble in alcohol in the
proportion of I to 30 parts, in glycerin, in dilute am-
monia, and in solution of bicarbonate of sodium.
Therapeutic Applications.-Saccharin is employed
as a sweetening agent for the food of diabetic patients,
and as a corrective. It is likewise a good antiseptic, and
is said to have produced marked benefit in the treatment
of cystitis.
Administration.-The dose of saccharin is indefinite.
For external application-as a mouth-wash, for example
-the following combination may be used: To io grains
(o.65 gramme) each of saccharin and bicarbonate of
sodium, dissolved in Io fluidrachms (37.25 grammes),
are added 10 or 20 grains (0.65 or 1.30 gramme) of sali-
cylic acid, and then enough spirit to make I ounce
(30.00 grammes).
SALACETOL.
Salacetol, or salicylacetol, as it is also termed, is ob-
tained from the interaction of sodium salicylate and
monochloracetone. A transformation is produced, and
the resulting substance is then represented by the for-
mula C H.COCH.02C.C6H4OH + NaC1.
Physical Properties.-Salicylacetol appears in long
crystalline needles that melt at 159.8 F. (710 C.). This
drug saponifies readily with soda-solution or ammonia.
Solubility.-Salacetol is easily soluble in warm alco-
hol, in ether, chloroform, benzene, and bisulphide of
carbon; less soluble in cold alcohol; sparingly soluble
in hot water; it is insoluble in cold water.
Physiological Action.-Clinical observations have
shown that salicylacetol diminishes the amount of the
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/173/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.