Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 152
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152 NOTES ON THE NEWER REMEDIES.
are chiefly due to a cardiac influence. This drug appears
to be a heart-poison, and death is generally caused by
cardiac failure.
Respiration.-The rate of the respiratory movements
at first is increased, followed by a decrease. This func-
tion is dangerously disturbed by pental.
Pupil.-The pupil is dilated under the influence of
the drug, this phenomenon probably being of a centric
origin.
Therapeutic Applications.-The chief use of pental
is that of an anaesthetic, but as such it is not so efficient
as ether or chloroform; besides, the drug in question
has a tendency to depress the circulation to a dangerous
degree. It has been employed chiefly in minor surgical
operations, such as opening buboes, abscesses, etc., and
in dental practice.
Administration.-Pental may be administered by in-
halation in doses of from I4 to 2'2 drachms (5 to io
grammes). As a local remedy it may be applied in the
form of a spray.
Toxicology.-The narcosis produced by pental is not
unattended by deleterious effects. This drug has already
caused death in the human being. Among the disagree-
able after-effects of this agent may be mentioned nervous
excitability, tremors of the extremities, a staggering gait,
difficulty of speech, dizziness, redness of the face, and
headache. This drug has caused erythema, and even
tetanic spasms. There is often produced by this medic-
ament the Cheyne-Stokes type of respiration, this phe-
nomenon being exceedingly dangerous. It is asserted
also that albumen and blood in the urine have appeared
after pental narcosis.
PEREIRINE.
An alkaloidal principle obtained from Pao pereiro so
called, or Geissospermnum ileve, belonging to the Apocy-
nacev. No thorough chemical study of this alkaloid
has been published. Two salts, the hydrocklorate and
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/151/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.