Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 154
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154 NOTES ON THE NEWER REMEDIES.
this agent acts particularly on the sensory portion of the
cord.
Circulation.-Small doses of this drug stimulate the
circulation, causing a rise of the arterial pressure, accel-
eration of the pulse-rate, and an increase of the cardiac
force. Large amounts are depressant. To produce
these phenomena this agent acts chiefly upon the heart.
Phenacetin causes a chocolate or dark color of the
blood, said to be due to methaemoglobin.
Respiration.-This function is stimulated, through a
centric action, by large quantities of the drug. Mod-
erate doses have no effect on respiration.
Urine.-This liquid becomes dark yellow under the
influence of phenacetin, and responds to sugar reactions.
Phenacetin is said to act somewhat as a diuretic.
Temperature.-Phenacetin does not seem to affect
normal temperatures. In fever this drug reduces the
heat mainly by decreasing its production. Phenacetin
apparently also increases, though slightly, heat-dissipa-
tion.
Therapeutic Applications. Phenacetin is useful as an
analgesic and an antipyretic. It is considered in many re-
spects superior to, and the safest of, the coal-tar derivatives.
As an antipyretic it has been employed with apparent suc-
cess in typhus and typhoid fevers, in phthisis, and in
other febrile disorders. As an analgesic good results
have been produced by it in the treatment of neuralgia,
migraine, whooping-cough, articular rheumatism, and in-
fluenza. This medicament is certainly of value in the
insomnia caused by a high febrile state. Locally, it has
been used in the treatment of acute rhinitis.
Administration.-The dose of phenacetin varies from
3 to 15 grains (o.19 to I gramme). Even so high a dose
as 90 grains (6 grammes) has been administered. The
drug is best given in cachets or suspended in mucilagi-
nous drinks. The powder may be applied locally.
Toxicology.-Untoward effects may follow the use of
phenacetin, these consisting of dyspncea, precordial pain,
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/153/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.