Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 143
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in chocolate lozenges. The dose varies from I to 510
grain (0.000ooo65 to 0.0013 gramme).
Toxicology.-Untoward effects are apt to follow the
use of nitroglycerin, such as headache, a slow, irregular
pulse, dilated pupils, a scanty urine containing large
amounts of pigment, muscular weakness, a sense of
constriction around the forehead, and pain over the
cardiac region.
OREXIN.
The above common name is given to the phenyl-
di/ydro-quiiaolin htydroclorate, a derivative of chino-
lin, its chemical formula being C6H4,-CH2N,CHN,-
C6IHHCI + H20.
Physical Properties. Orexin is a grayish, odorless
powder, made up of brilliant crystals, with a tendency
to efflorescence on exposure. It has a bitter and pun-
gent taste.
Solubility.-This drug is soluble in water and in
alcohol.
Therapeutic Applications.-Orexin is claimed to
possess stomachic virtues, and is said to be an excellent
appetizer. This remedy is especially valuable in the
anorexia of anemia, early phthisis, and that occurring
in chronic gastric catarrh. This medicament appears to
stimulate principally the secretion of hydrochloric acid.
The uncombined or basic form of orexin has of late been
recommended for use, on the ground that in this form
the agent does not cause any pungent sensation on the
mucous membrane. Orexin has been employed in em-
physema, in insufficiency of the cardiac muscle, and in
nephritis, in which cases, it is asserted, the appetite is
increased and the nutrition essentially improved. This
remedy has been warmly lauded also in the treatment
of the vomiting of pregnancy.
Contraindications. This drug is contraindicated in
gastric ulcer.
Administration.-The dose of orexin is 3 grains (0.2OREXIN.
I43
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/142/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.