Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 145
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O UABAIN
odor. It boils at 2120 F. (Iooo C.), and in solution has
a burning taste.
Therapeutic Applications.-Osmic acid has of late
been highly recommended in the treatment of goitre.
It is asserted to be of service also in scrofula, in can-
cerous ulcers, and in neuralgia, and particularly in sci-
atica. Epilepsy is said to be greatly benefited by this
remedy.
Administration.-This acid is best administered hypo-
dermatically in doses of from -0- to Al of a grain (o.ooI 3
to 0.0054 gramme). Internally, it may be given in pill
form in the same quantities.
OUABAIN.
This is the glucosidal principle of the ouabaio plant,
Acocanthera ouabal'o or Carissa shtimperi, belonging to the
Apocynacee. This glucoside is said to be obtained also
from the seeds of Strophantlzus glabrzs. This principle
has the chemical composition C30H4,O02.
Physical Properties.-Oztabain is a white crystalline
body, without odor, and having a slightly bitter taste.
It has a melting-point of 3920 F (2000 C.).
Solubility.-This drug is readily dissolved in hot
water and in spirit, sparingly soluble in cold water, but
insoluble in alcohol, chloroform, and anhydrous ether.
Physiological Action. The general action of ouabain
is similar to that of strophanthine.
Circulation.-The heart is slowed at first, owing to a
stimulation of the cardio-inhibitory apparatus and to a
direct cardiac action. The pulse is afterward decreased
in rate, fiom depression and final paralysis of cardio-
inhibitory function. The blood-pressure is primarily in-
creased through vaso-motor spasm, centrally and periph-
erally; it is secondarily decreased by cardio-inhibitory
stimulation; and is again increased, due partly to in-
creased heart-action and continued vaso-motor spasm.
Poisonous doses paralyze the heart-muscle and the vaso-
motor system.
10I45
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/144/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.