Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 142
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142 NOTES ON THE NEWER REMEDIES.
alleged to be an effective physiological antidote to
strychnine.
Toxicology.-Nicotine-poisoning is manifested by the
following marked symptoms: great depression; giddi-
ness, with feeling of intense wretchedness and weakness;
skin cold, clammy; pulse rapid, running, and finally im-
perceptible; dyspnoea; muscular tremblings; and some-
times convulsions. Death occurs from general collapse.
In cases of poisoning the treatment should consist in
washing out the stomach, the administration of cardiac
and respiratory stimulants such as strychnine and digi-
talis, and the application of external heat and rubbings.
In the mild forms of poisoning, such as that occurring
from excessive smoking, the administration of Hoffman's
anodyne in ice-water has been recommended.
NITROGLYCERIN.
Nitroglycerin, commonly called glonoin or trinitritn,
is the trizitrate of glycerol, obtained by the action of sul-
phuric and nitric acids upon glycerin. Its formula is as
follows : C3H5(O.NO,)3.
Physical Properties.-Nitroglycerin is an oily sub-
stance, colorless and odorless, and of a sweetish taste.
It has a sp. gr. of I.6o.
Solubility.-Trinitrin is soluble in alcohol and in
ether, but is insoluble in water.
Physiological Action.-The action of this substance
is the same as that of the other nitrites; it is, however,
not so fugacious as the nitrite of amyl nor so persistent
as the nitrites of potassium and sodium.
Therapeutic Applications.-This remedy is a power-
ful sedative in nervous disorders, and has been used with
excellent results in the treatment of angina pectoris, in
sick headache, in asthma, and in sea-sickness. It has
been employed successfully also in epilepsy, especially
in petit mal, in puerperal convulsions, and in Bright's
disease.
Administration.-Nitroglycerin is best administered
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/141/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.