Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 146
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146 NOTES ON THE NEWER REMEDIES.
Respiration.-The action of ouabain on this function
is irregular. Respiration appears, however, to be gener-
ally primarily increased in rate and secondarily dimin-
ished, in both cases by a centric action.
Nervous System.-Ouabain decreases and finally
abolishes reflex action, chiefly by paralyzing the sensory
nerves. The motor nerves are also paralyzed by
poisonous ~mounts of this drug, especially when applied
locally. This agent apparently has no action on the
central nervous system.
Muscular System.-The striated muscles are paralyzed
by a direct action of ouabain.
Eye.-This drug causes pronounced corneal anaes-
thesia, and it is stated that it also produces contraction
of the pupil accompanied with an increase of intra-ocular
tension and enlargement of the eyeball.
Digestive Tract.-Ouabain produces emesis by a cen-
tric influence, and increases peristaltic movements.
Urine.-This drug acts as a diuretic, probably through
increased blood-pressure.
Therapeutic Applications.-Although ouabain is a
local anaesthetic to the conjunctiva and cornea, it has
not been employed as such. This drug has been used
internally, principally as a powerful antispasmodic, and
is said to be of especial value in the treatment of whoop-
ing-cough of children.
Administration.-The dose of ouabain is g- of a
grain (0.00004 gramme) every three hours for a child
five years of age.
PAMBOTANO.
This plant is the Calliandra houstoni of the Legumino-
see family. No thorough chemical analysis of it has as
yet been made.
Therapeutic Applications.-This drug is claimed to
be of service as an antiperiodic in the treatment of neur-
algias, and especially of fevers of malarial origin. It has
been employed with asserted good results in diseases
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/145/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.