Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 161
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PIPERAZIN.
may be set down as from s to - of a grain (o.oi to 0.02
gramme).
PIPERAZIN.
Also termed piperazidin, diet/tylenediamizn, dispermin,
and ethylenimin; obtained by the action of ammonia on
bromide or chloride of ethylene, its chemical nature
being represented by the formula C4H,0N2.
Physical Properties.-This drug is a crystalline body
having a melting-point of from 219.20 to 224.6 F. (1040
to o7 C.); it boils at 2920 F. (1450 C.). The aqueous
solution is practically tasteless.
Solubility.-P1erazin is exceedingly soluble in water.
Physiological Action. No researches have been
made to determine the exact action of this agent. It is
said, however, that the drug enters into combination
with uric acid to form the urate of piperazin, yet there is
an increase in the amount of urea with a corresponding
diminution in the elimination of uric acid. This fact in-
dicates that the process of oxidation is quite complete.
The affinity of piperazin for uric acid promotes the trans-
formation of this acid into urea.
Therapeutic Applications. The chief and most valu-
able use of pperazidin in medicine is as a solvent for
uric-acid and urate concretions, in which action it has,
up to the present time, no rival as a medicament with
this power. It is undoubtedly an invaluable remedy in
gout, rheumatic arthritis, and other similar affections.
It has produced excellent results in the pruritus of the
uric-acid diathesis. The use of the drug is said to have
been of service in the treatment of renal colic and in
urinary hemorrhage. Hypodermatic injections into
gouty deposits, and even local applications to gouty
swellings, are recommended. Piperazin has given good
results in the treatment of diabetes.
Administration.-The dose of piperazin is 15 grains
(I gramme). It may be administered by the stomach
and subcutaneously. The remedy can also be applied
11I6I
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/160/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.