Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 165
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P YOKTANIN.
Physiological Action.-This agent stains the skin.
Unlike other germicides, it does not coagulate albumin.
Locally applied, it is a strong irritant. Internally, given
in sufficiently large amounts, it has a sedative effect on
both motor and sensory nerves. It produces at first a
slight increase of the reflexes. It also causes a condition
of methmoglobinuria.
Therapeutic Applications.-Pyoktanin has been em-
ployed extensively as a general antiseptic in the local
treatment of ulcers and chancres, and* also in that of
whitlow and anthrax. It is said to be of value in diseases
of the eye, such as parenchymatous keratitis, ophthalmia,
corneal ulcers, choroiditis, purulent conjunctivitis, iritis,
tinea tarsi, and particularly in sloughing keratitis; in
affections of the ear, such as otitis media; in diseases of
the nose and throat, such as nasal diphtheria and ozena
of whatever nature, aphthae, purulent discharges, and
tubercular ulcerations of the soft palate. Pyoktanin has
rendered good service in epithelioma and in many para-
sitic disorders of the skin. This drug, subcutaneously
injected, is alleged to have produced good results in the
treatment of malignant growths, such as carcinoma and
sarcoma. It is lauded as a most efficient analgesic, and
it is reported to be of special value in acute articular
rheumatism, ataxia, and alcoholic neuritis, and in a large
variety of neuralgias. This medicament has produced
good results in the treatment of gonorrhcea.
Administration.-This remedy is given by the mouth,
in doses of from I to 72 grains (0.06 to 0.5 gramme), and
even as high as 15 grains (I gramme), a day. Hypoder-
matically, about 5 of a minim (0.05 gramme) of a 2 per
cent. solution can be given. For local use watery solu-
tions of the strength of I : 3000 or I : 1000 may be em-
ployed. Pencils of pyoktanin are also used for local
applications.
Toxicology.-Pyoktanin is apt to cause poisonous
symptoms. The most frequent untoward effects observed
under the use of the drug have been nausea, diarrhea,I65
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/164/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.