Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 162
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162 NOTES ON THE NEWER REMEDIES.
locally in I or 2 per cent. solutions mixed with water and
spirit, I to 4 respectively.
PIPERINE.
An alkaloidal principle obtained from the fruit of Piper
nigrum, or common black pepper. Its chemical compo-
sition is C17H19NO3.
Physical Properties.-Perine when pure is colorless
and has practically no taste. It generally occurs as a
yellowish resin with a pungent taste.
Solubility.-This drug is readily soluble in sulphuric
and acetic acids, somewhat soluble in alcohol, but in-
soluble either in cold or hot water or in ether.
Therapeutic Applications.-Piperine has been em-
ployed as an antipyretic and laxative; its use, however,
has not been extensive.
Administration.-The dose of this remedy, given in
powder or in pill form, is from I to Io grains (0.06 to
0.65 gramme).
PIPERONAL.
This drug is known also under the name of heliotropin.
It is obtained from piperic acid by oxidation, and has the
composition C8H603.
Physical Properties.-This substance appears in the
form of small white crystals.
Solubility.--P personal is soluble in alcohol and ether,
but not in water.
Therapeutic Applications.-This remedy has been
proposed as an antipyretic and antiseptic, but its use is
1 Beta-nitrophkenylpiperazin, with a melting-point of 264.20 F. (1290 C.),
diacetyvpiperazin, with a formula of CHN.2CHO and a melting-point of
271.30 F. (138.50 C.), and other derivatives of piperazin and allied com-
pounds have been prepared, but have not yet been tried in practical
medicine. To the tartrale of diproplenediamin, or dimethylpiperazin.
the common name of Icetol has been given. This drug is said to undergo
oxidation in the organism into a carbonate, and to thus alkalinize the blood.
It is asserted to have done good in gouty diseases, but the reports as to the
therapeutic value of this agent are as yet insufficient.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/161/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.