Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 171
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RESORCIN.
Solubility.-This drug is readily soluble in I 2 parts
of water, in alcohol, and in ether; difficultly soluble in
chloroform, benzene, or carbon disulphide.
Physiological Action.-Little is known of the physi-
ological action of resorcin; locally, it is an irritant. It
appears to act upon the central nervous system, causing,
in sufficiently large amounts, tremors and even epilepti-
form and tetanic convulsions accompanied with loss of
consciousness. The respiration and the action of the
heart are disturbed, and during the convulsive action the
drug produces a rise of the bodily temperature followed
by a marked fall below the normal. Resorcin acts di-
rectly upon the heart, and slows the pulse apparently by
pneumogastric stimulation. In general action .this agent
resembles carbolic acid, and, like this medicament, it
destroys lower forms of organisms. Resorcin arrests
putrefaction.
Therapeutic Applications.-Resorcin is reputed to
possess antiseptic and antipyretic virtues. As an anti-
septic it has been used in diseases of the stomach, dys-
entery, cholera infantum, etc. As an antipyretic it has
been used in febrile affections generally, such as typhoid
fever, malaria, measles, etc., and especially in the hyper-
pyrexia of septicamia and in those febrile disorders
attended with gastro-intestinal derangements. It has
also been employed as a local remedy, with asserted
success, in diseases of the upper air-passages, especially
in ulcerative laryngeal phthisis, laryngeal ulcers, and
other similar maladies; in gonorrhea, diphtheria, croup,
and whooping-cough ; in cutaneous affections, partic-
ularly eczema, psoriasis, etc. This drug is favorably
spoken of as an antispasmodic against asthma. It has
likewise rendered good service in the local treatment of
diseases of the ear and nose.
Administration.-The dose of resorcin is from I to 2
grains (o.o6 to 0.12 gramme). For local use, solutions
of the strength of from I to 3 per cent. may be used, or
ointments of the strength of 5, Io, or as high as 25 per
cent.I7I
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/170/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.