Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 114
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I 14 NOTES ON THE NEWER REMEDIES.
sedative and hypnotic, and is especially useful in mental
disorders, neuralgias, sexual over-excitement, and sper-
matorrhcea.
Contraindications.-Although an excellent remedy
in the diseases mentioned, hyoscine has serious draw-
backs to its use. It ought not to be administered in the
sore throat of scarlet fever, from the fact that it may
cause spasm of the glottis, and hence suffocation. It
should not be employed in the insomnia of cardiac
disease, nor should the remedy be given to asthmatic
patients.
Administration.-The dose of hyoscine is from T i
to -o grain (o.ooo65 to 0.003 gramme); for hypoder-
matic use, from 200 to - of a grain (0.00032 to 0.0013
gramme).
Toxicology.-Untoward effects under the use of hyos-
cine are common. The chief one is paralysis of the
pharynx, and probably also of the laryngeal muscles.
Poisoning by this substance may resemble that caused
by atropine, although the respiration and the pulse-rate
may be decreased by hyoscine. At all events, the poi-
soning should be treated as one produced by belladonna.
HYPNAL.
This is a mixture of chloral and antipyrin. It is chem-
ically known as the tri-clloral-dctlydpelznyl-dimethylpyra-
zolon.
Physical Properties.-This drug is tasteless and odor-
less, is made up of rhombic crystals, and has a melting-
point of from 136 to I40 F. (58 to 600 C.).
Solubility.-Hyplnal is soluble in water in the propor-
tion of 5 to 6 parts.
Therapeutic Applications.-This remedy is generally
employed with good effect as an antispasmodic, and par-
ticularly as a hypnotic. It has been beneficial in neur-
algic insomnia as well as in that arising from phthisis.
Administration.-The dose of hypnal is from I5 to
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/113/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.