Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 201
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THE OBR OMINE.
dioxide and urea. This drug is rapidly eliminated by
the kidneys.
Therapeutic Applications.-The salts are employed
in practical medicine, though not very extensively, as
germicides and antipyretics especially. They have been
used with apparent success in the treatment of gonor-
rhoea. Thallin seems to be quite active in diminishing
the fever of phthisis. It is particularly recommended
in the treatment of typhoid fever.
Contraindications.-The use of thallin is contraindi-
cated in nephritic disease and in valvular affections of the
heart.
Administration.-Either salt is given in doses of from
2 to 4 grains (0.12 to 0.25 gramme), and even as high as
8 grains (0.50 gramme). For injections in gonorrhoea
the sulphate may be applied in I I2 per cent. solutions
by itself, or in combination with tannin and nitrate of
silver. Bougies smeared with a 2 per cent. ointment
made with cacao butter may be employed.
Toxicology.-Nausea and vomiting, excessive sweat-
ing, cyanosis, and collapse are quite often caused by
thallin. Chilliness, particularly, is a most disagreeable
symptom produced by this medicament. In chronic
poisoning the drug diminishes the number of red blood-
corpuscles and causes destructive changes in the kidneys.
THEOBROMINE.
This alkaloidal body is extracted from the cacao-plant
(Theobroma cacao), and has a composition of CH,N40,.
Physical Properties.- Theobromnine occurs as a color-
less crystalline powder having a bitter taste.
Solubility.-This alkaloid is soluble in alcohol and
in ether, and slightly so in water.
Physiological Action.-This drug in physiological
doses seems to exercise no perceptible action upon the
circulatory system of mammals. The pulse and blood-
pressure remain unchanged. Only in comparatively large
amounts does theobromine cause a reduction of the press-20I
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/200/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.