Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 195
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SULPHONAL.
Solubility.-This drug is soluble in alcohol and in
ether; also in ioo parts of cold water and in 20 to 15
parts of boiling water.
Physiological Action.-The action of sulphonal is
not well known. It is said to act as a depressant to the
nervous system, decreasing reflex activity by stimulation
of Setschenow's centres. In moderate amounts this drug
appears to exercise no marked action on the circulation.
Its influence on metabolism is nil. Sulphonal, given in
small quantities, appears to be entirely destroyed in the
body, it being changed into a sulphuretted substance.
It is said to act slightly as a diuretic.
Therapeutic Applications.-The chief properties of
sulphonal are those of a hypnotic. As such it has been
used extensively in a variety of nervous disorders whose
principal symptom is sleeplessness with or without the
existence of pain. This drug is of special value in some
forms of insanity, in neurasthenia, and in hysteria. This
medicament has likewise been recommended in the treat-
ment of diabetes mellitus.
Administration.-The dose of sulphonal is from 15 to
30 grains (I to 2 grammes), and it is best administered
in capsules or in mucilage of acacia.
Contraindications.-This drug should not be used in
diseases of the heart.
Toxicology.-Sulphonal is capable of causing serious
symptoms. Sulphonism is made manifest by cephalalgia,
buzzing in the ears, weakness, and physical and mental
torpor. The symptoms of chronic poisoning are consti-
pation and vomiting accompanied with ataxic nervous
troubles. Palpitations, swelling of the joints, pains in
the lower extremities, and a rubeolar exanthem have
been observed under the action of this drug. In some
instances there may occur difficulty of speech, oedema
of the eyelids, ptosis, cyanosis, and somnolence. When
any one of these symptoms appears this medicament
should be suspended immediately.I95
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/194/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.