Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 190
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190 NOTES ON THE NEWER REMEDIES.
disorders as hysteria and neurasthenia. This drug is
claimed to be of special service in the treatment of ex-
ophthalmic goitre, by controlling the general symptoms
and reducing the pulse-rate.
Administration.-Sulphate of sparteine may be given
in single doses of from 4 grain to 2 grains (0o.o03 to 0.12
gramme).
Toxicology.-This drug may cause general nervous
depression, and among the early toxic effects produced
may be mentioned tremors, inco-ordination of move-
ments, and even clonic and tetanic convulsions.
SPASMOTIN.
Under the name of spasimotin or that of sphacelotoxin
a new poisonous body has of late been extracted from
ergot. Chemical analysis gives it the formula C20H10t,.
Physical Properties.-In the pure state spasmotin
occurs in the form of an amorphous yellow power.
Solubility.-This substance is soluble in alcohol, sul-
phuric and acetic ethers, and benzene. It is insoluble in
water, dilute acids, and petroleum ether. The drug
forms salts with alkalies.
Physiological Action.-The name of spasmotin has
been applied owing to the fact that the drug is able to
contract the small arteries. It is affirmed that the well-
known action of ergot on the pregnant uterus resides
principally in spasmotin and its sodium salt.
Therapeutic Applications. - Though not yet em-
ployed in practical medicine, spasmotin is suggested as
a substitute for ergot. In experiments upon the lower
animals doses of from 2 of a grain to 15 grains (0.04 to I
gramme) gave satisfactory results.
SPERMIN.
A substance extracted from the seminal fluid of various
animals, the chemical composition of which is said to be
C2H5N.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/189/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.