Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 127
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MALA KIN.
and as a gargle for foul breaths. In the form of an in-
jection it has been found highly serviceable in the treat-
ment of acute blennorrhagia.
Administration.-This remedy is used locally in so-
lutions of the strength of from 3 to 5 per cent. For
injections-as in blennorrhagia, for instance-solutions
of the strength of I per cent. may be employed.
MALAKIN.
This name is applied to salicyl-paraphenetidin, a sub-
stance closely related to phenacetin. The chemical com-
position of malakin is represented as-
/OC2H5
C6H4\N C -C6H4OH.
H
Physical Properties.-Salicyl-paraphenetidin appears
in the form of small, fine, bright-yellow needles melting
at 197.6 F. (920 C.). It contains about 50 per cent. of
salicylaldehyd; it can be decomposed by mineral acids,
and is then split up into salicylaldehyd and paraphenet-
idin. It gives a yellow color with soda-lye.
Solubility.-Malakin is soluble in hot alcohol and
in soda-lye, sparingly soluble in cold alcohol, and insol-
uble in water.
Therapeutic Applications.-Though acting more
slowly than antipyrin and antifebrin, malakin has been
found to exercise a beneficial influence in febrile disor-
ders, such as typhoid fever, pneumonia, tuberculosis,
scarlet fever, and erysipelas. The antipyretic action is
said to be unaccompanied with disturbances of the cir-
culation. This drug has likewise given good, but not
decided, results in the treatment of neuralgia, although
it does not completely destroy the pain in these cases.
It is said to be well borne by the stomach.
Administration.-The single dose of salicyl-para-
phenetidin is put down as from 72 to 15 grains (0.5 to
I gramme), and is best given in wafers or capsules. ForI27
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/126/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.