Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 102
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102 NOTES ON THE NEWER REMEDIES.
GUAIACOL.
Guaiacol is designated also by the name met/,ylpyro-
cateckin. It is obtained from beechwood tar creosote,
and it is said to contain from 60o to 90 per cent. of creo-
sote. Its formula is C6H4OHOCH3.
Physical Properties.-This drug occurs as a liquid
substance having a pleasant odor. It boils at fiom
402.8 to 404.6 F. (2o60 to 207 C.), and its sp. gr. at
590 F. (I5o C.) is I.133-
Solubility.- Guaiacol is soluble in water in the pro-
portion of I to 85, and in petroleum benzene in the pro-
portion of I to 8.
Therapeutic Applications.-At present guaicol is
extensively used in the treatment of tuberculosis, espe-
cially during the early stages of the disease, as an advan-
tageous substitute for creosote. In tubercular and in
other febrile disorders the drug has done good even
when locally applied. Thus used, its antipyretic effects
have been decided.
Administration.-This medicament is best given after
meals, in alcoholic solutions, mixed with cod-liver oil, or
in capsules, in doses of from 5 to 10 minims (0.30 to o.6o
gramme). It may be administered also in the same
amounts by inhalation or hypodermatically. Locally, the
dose may be put down as about 30 minims (2 grammes),
which must be rubbed in slowly.'
1 Oleo-creosote is composed of oleic acid and creosote, and is prepared
with the aid of phosphorus trichloride. It occurs as a yellowish liquid
having a creosote-like taste. It is readily solul)le in absolute alcohol, spar-
ingly so in 90 per cent. alcohol, and insoluble in water. It contains 33
per cent. of creosote, and is miscible in all proportions with fitty oils, ether,
benzene, carbon bisulphide, chloroform, and oil of turpentine. Oleo-creo-
sote is said to be decomposed in the intestines by the alkalies, and ppears
to be non-poisonous when given by the stomach, and even when adminis-
tered hypodermatically, in doses in which either creosote or guaiacol would
prove deleterious. Oleo-guaiacol is a substance prepared in a manner
similar to that of the oleo-creosote, and is also recommended as a thera-
peutic agent of value.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/101/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.