Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 108
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Io8 NOTES OAN THE NEWER REMEDIES.
HYDRACETIN.
This hydrazin compound, also commonly called pyro-
din, is the acetyl-phenyl hydrazin, with a formula of
C6HHN-NHCH3CO.
Physical Properties.-Hydracetin occurs as a color-
less, odorless, and almost tasteless substance, and is made
up of prisms. It boils at from 262.4 to 264.2 F. (I280
to I29 C.).
Solubility.-Hydracetin is soluble in alcohol, and in
water in the proportion of I to 50.
Physiological Action. This drug acts particularly
on the lower nervous system, diminishing reflex activ-
ity. Upon the circulation it acts as a depressant; the
pulse-rate is lessened and the arterial pressure is
lowered by influencing the vaso-motor centres. It
is said to exercise a destructive action upon the red
blood-corpuscles. Hydracetin diminishes the bodily
temperature, this effect being accompanied by marked
sweating.
Therapeutic Applications. This drug has been em-
ployed, with little or no beneficial effect, as an antipyretic
in such diseases as rheumatism of the joints and tetanus;
its chief uses at present are confined to cutaneous dis-
orders, especially psoriasis, in which it is resorted to in
the place of chrysarobin. As an antipyretic it must be
given with extreme caution.
Administration.-The dose varies from 2 to 3
grains (0o.o03 to o.18 gramme). For local applications
an ointment of the strength of 10 per cent. may be
employed.
Toxicology.-Pyrodin is a poisonous substance. It
may produce such symptoms as chills, cyanosis, dimin-
ished bodily temperature, profuse sweating, and disturb-
ances of respiration and circulation-in fact, all the
phenomena of collapse. Anaemia and methemoglo-
binuria may also result from the continued use of the
drug.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/107/: accessed April 30, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.